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Laurocapram Pharmaceutical Excipients
Nanjing Hongzun Chemical Plant Co., Ltd.

Laurocapram(Azone) Pharmaceutical Excipients
Item Index
Appearance Colorless transparent viscous liquid
Content(%) 97.0—102%
Caprolactam(%) ≤0.1
Bromide(%) ≤0.1
Heavy metal(ppm) ≤10
Refractivity 1.470-1.473
Relative density 0.906-0.926
PH value Neutral
Packing & Storage
Packing in 10kg carton(500ml/bottle), 20kg paper barrel, 25kg drum
Storage 20℃, 2 years.
Shipping Room temperature in China; may vary elsewhere
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General information
Chemical & Physical Properties
Safety Information
Synthetic Route
Common Names Laurocapram | Azone | 1-dodecyl-hexahydro-azepin-2-one
CAS No. 59227-89-3 Boiling Point (℃) 404.9±14.0 °C
Molecular Weight 281.477 Melting Point (℃) '-7ºC
Appearance Colorless liquid Vapor Specific Gravity 0.9±0.1 g/cm3
HS Code 2933990099 Flash Point (℃) 165.2±10.7 °C
Solubility Insoluble in water, soluble in ethanol, ether, acetone and benzene Autoignition Temperature (℃)
Safety Phrases
WGK Germany
Packaging Group
Hazard Class
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.

1) In a reaction vessel equipped with a stirrer, add dodecane bromide and solvent oil, control the stirring speed to 30120rpm, heat the temperature of the solvent oil solution to 4595°C, add caprolactam, tetrabutylammonium bromide TBAB, hydroxide Sodium, reaction 38 hours; Bromododecane: caprolactam: sodium hydroxide is 1mol: 0.81.4mol: 0.82mol, solvent oil is greater than the quality of total raw material of reaction, a small amount of phase transfer catalyst TBAB tetrabutyl ammonium bromide;

Add an appropriate amount of water to the reaction solution to dissolve sodium hydroxide and the sodium bromide generated by the reaction, let stand to separate layers, and separate the lower aqueous solution; after the upper organic layer recovers the solvent oil under normal pressure, it is distilled under reduced pressure to obtain the finished product of azone. More than 92%, Azone content is more than 95%.

Frequently Asked Questions

Application of Laurocapram in Medicine and Cosmetics Industry

Laurocapram has a noticeable effect of drug penetration enhancement and synergism, which can promote the body's absorption and utilization of active drug ingredients. It has a good curative effect on the treatment of dermatitis, psoriasis, and eczema. Its mechanism of action is to enhance the stratum corneum's fluidity and make the stratum corneum's lipids irregularly arranged, thereby increasing the osmotic absorption of drugs. It can be used for carrying out and controlling the release of almost all kinds of antibiotics, hormones, steroids, and antiviral and antitumor drugs, especially for various plant extracts and alkaloids. A dosage of 0.5% to 2% has a strong transdermal penetration-enhancing effect. Laurocapram is widely used in cardiovascular, anti-inflammatory and analgesic, anthelmintic, antiviral, and antitumor drugs and some drugs with poor transdermal properties. It can promote the body's transdermal absorption of the active ingredient of the drug, exert a strong pharmacological effect, and reduce the dosage of the main drug and the cost. Such as containing 1.8% laurocapram can increase the penetration of the anticancer drug fluoropyrimidine by 80 times.

As a drug adjuvant, laurocapram does not react chemically with the drug to be penetrated. It has no pharmacological effect itself, thus adding some traditional drug delivery methods. Laurocapram can be used to prepare paracetamol, aminophylline, erythromycin, phenobarbital, amikacin, and other medicines for external use, such as creams, liniments, etc., thus avoiding the toxic and side effects of oral administration on the human body, improve the therapeutic effect of topical application. Laurocapram can also be used as an additive for various nutritional, curative, and functional health-care cosmetics, making the product more comfortable and smooth, non-irritating and non-damaging to the skin, and excreting quickly with less skin residue.

In addition, laurocapram also has a strong antibacterial effect. It can destroy the cell wall structure, causing many enzymes in the bacteria to leak out and lose, leading to the apoptosis of bacteria and spores.